
Gouranga Saha
Biotechnology consultant and cancer biology researcher (PhD)
Network
334 connectionsSummary
Work
Education
Writing
UPS and Kinases—Gatekeepers of the G1/S Transition
January 1, 2025Review discussing coordination between ubiquitin–proteasome system (UPS) and kinases in regulating the G1/S cell-cycle transition and implications for cancer biology. Cited by 2.
Glioma nanotherapy: Unleashing the synergy of dual-loaded DIM and TMZ
September 1, 2024Peer-reviewed article reporting that PLGA-based dual loading of TMZ and DIM enhances drug delivery across the blood–brain barrier, increases DNA damage and apoptosis, reduces tumor burden and systemic toxicity in preclinical glioma models. Cited by 12.
PLGA-based dual-loaded nanoformulation of DIM and TMZ - An advanced clinical strategy for brain cancer treatment in a combinatorial approach
May 1, 2023Preprint describing development of a PLGA-based nanoparticle co-encapsulating Temozolomide and 3,3'-diindolylmethane (DIM) to enhance brain tumor drug delivery and therapeutic synergy in preclinical models. Cited by 6.
USP7 - a crucial regulator of cancer hallmarks
April 1, 2023Review summarizing USP7's roles across cancer hallmarks and discussing USP7-targeting strategies and inhibitor development challenges. Cited by 89.
A small HDM2 antagonist peptide and a USP7 inhibitor synergistically inhibit the p53-HDM2-USP7 circuit
April 1, 2023Study reporting a helically constrained peptide that inhibits p53-HDM2 interaction and demonstrates synergistic anti-proliferative effects when combined with a USP7 inhibitor. Cited by 2.
USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma
October 1, 2022Research article identifying XIAP as a USP7 deubiquitination substrate and describing a p53-independent pathway by which USP7 promotes glioma progression; includes in vitro and in vivo combinatorial inhibition results. Cited by 32.
The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer
January 1, 2025Review of vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer, discussing USP7-targeting strategies and implications for therapy. Cited by 9.
USP7 (Ubiquitin-Specific Protease 7)
January 1, 2018Encyclopedia chapter summarizing USP7's functions, regulatory mechanisms, and roles in cancer signaling pathways.
Cellular homeostasis or tumorigenesis: USP7 playing the double agent
January 1, 2018Article discussing USP7's dual roles in maintaining cellular homeostasis and promoting tumorigenesis, highlighting context-dependent functions.
The regulation of deubiquitinase USP7 through various signaling network and its role in oncogenesis
Overview of regulatory mechanisms controlling USP7 and its role in oncogenesis.
Comprehensive insights on COVID-19 host-pathogen interactions
Book chapter detailing the mechanisms of host-pathogen interactions specifically related to COVID-19, contributing to understanding infection pathways and immune responses.
Advances in COVID-19 therapeutic strategies
A book chapter exploring recent advancements in therapeutic approaches to treat COVID-19, covering antiviral drugs, immunomodulators, and vaccine development.
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