
René Lomelí Ojeda
Partner at 500 Global, building the LatAm startup ecosystem
ren-lomel
Mexico City, Mexico
Joined May 2026
Summary
René Lomelí Ojeda is a key figure in the Latin American startup ecosystem, serving as a Partner at 500 Global. He has been instrumental in its development since 2013, focusing on fostering investor relationships, enhancing brand presence, and collaborating closely with portfolio companies. His work spans acquisition strategies, startup growth, and fundraising, demonstrating a deep commitment to the region's entrepreneurial landscape. lafronterapodcast+1
As the host of the 'Ángeles de LatAm' podcast, René engages with angel investors across Latin America. Through these interviews, he delves into their personal investment journeys, strategic theses, and diverse portfolios, providing valuable insights into the regional investment landscape and contributing to the education of founders and aspiring investors. spotify+2
René actively mentors startups within the 500 Global ecosystem. He provides guidance and support, particularly to early-stage companies (Pre-Seed, Seed, and Series A), helping them navigate challenges, refine their strategies, and prepare for subsequent funding rounds. His hands-on approach reflects his dedication to nurturing the next generation of successful ventures. lafronterapodcast+1
His early career as a 'community builder' and organizer for Startup Weekend highlights his foundational role in cultivating entrepreneurial communities. This experience laid the groundwork for his extensive involvement in the LatAm startup scene, demonstrating a sustained passion for connecting founders, investors, and resources to drive innovation and growth. lafronterapodcast
René's investment focus at 500 Global is on early-stage startups in Latin America, with typical investments around $300k, providing 12-18 months of runway for traction. He is particularly interested in companies like Lineup (Pre-Seed, Sep 2022) and SPIDER FLEET (Seed, Aug 2017), indicating an active role in identifying and supporting promising ventures. lafronterapodcast+1