Paul Victor Santiago Raj
Postdoctoral researcher studying mitochondrial mechanisms in kidney disease
Summary
Work
Education
Projects
Writing
MARY1 restores mitochondrial homeostasis and accelerates renal recovery following acute kidney injury
August 1, 2025Preclinical study showing that MARY1 treatment after ischemia/reperfusion-induced acute kidney injury improves renal function, restores mitochondrial homeostasis, increases autophagy and β-oxidation, and promotes renal recovery in mice.
Discovery of a Novel, Potent, and Selective 5-Hydroxytryptamine 2B Receptor Antagonist that Induces Mitochondrial Biogenesis in the Kidney
May 1, 2025Describes identification and characterization of MARY1, a pyridinylpiperazine 5-HT2B receptor antagonist that induces mitochondrial biogenesis in renal cells and in vivo, including mechanistic signaling pathways and preclinical data.
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
February 1, 2025Integrative multi-omics and translational analysis exploring repurposing of pyrvinium pamoate for Merkel cell carcinoma; Paul Victor is a contributing co-author on this collaborative work.
Oral streptococci S. anginosus and S. mitis induce distinct morphological, inflammatory, and metabolic signatures in macrophages
August 1, 2023Study (preprint and later peer-reviewed) investigating differential innate immune and metabolic responses of macrophages to two oral Streptococcus species; Paul Victor is a co-author on the bioRxiv preprint and the peer-reviewed Infection and Immunity article.