Mohamad Ali Najia

Preprint reporting that inhibition of H3K9 demethylases KDM4A/C disrupts heterochromatin fidelity, induces replication stress and cGAS-STING signaling, and identifies KDM4 inhibition as a potential therapeutic vulnerability across lymphomas and other cancers.

Preprint describing a synthetic RNA export system enabling live-cell, transcriptome-scale profiling by packaging cellular RNAs into engineered virus-like particles for extracellular capture and analysis.

Journal article demonstrating that EZH1 repression facilitates in vitro differentiation and maturation of T cells from iPSCs and that EZH1-repressed iPSC-derived T cells (EZ-T cells) can produce developmentally mature T cells with diverse TCR repertoires and potent antitumor activity when engineered as CAR T cells.

Nature Cell Biology paper describing CellComm, an algorithm to infer intercellular communication and downstream signalling from single-cell and spatial transcriptomics, and its application to identify niche signals regulating HSPC emergence.