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Gopinath Prakasam

Gopinath Prakasam

Assistant Instructor — molecular cancer genetics and metabolism

gopinath-prakasam
Dallas, Texas
Joined February 2026

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Summary

Focused translational researcher in kidney cancer: Prakasam is centrally engaged in molecular cancer genetics and cancer metabolism research with a strong emphasis on translocation renal cell carcinoma (tRCC) biology, mouse and tumorgraft models, and identifying therapeutic vulnerabilities. nih+2
Active academic collaborator and author: He is a coauthor on multiple peer-reviewed publications and conference abstracts (JCI 2024, Cancer Res 2023 abstract, Cell 2025, Frontiers 2018), reflecting a steady publication record in cancer biology and translational studies. nih+2
International training and academic progression: Trained in India (Ph.D., Jawaharlal Nehru University) and progressed to postdoctoral and faculty roles at UT Southwestern, illustrating a trajectory from doctoral research in molecular cancer biology to postdoctoral translational research in a U.S. academic medical center. ac+2
Engaged in mechanistic and model-based therapeutic research: Work includes development and use of genetically engineered mouse models and tumorgrafts and involvement in studies that probe mechanisms (e.g., biomolecular condensates, mTORC1, MET/RET) with translational implications for kidney cancer therapy. nih+2

Work

Education

Writing

RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates

January 1, 2025

Multi-author study demonstrating that diverse oncofusion proteins promote biomolecular condensates that partition RNA polymerase II, revealing a shared molecular mechanism by which oncofusions can dysregulate transcription and drive cancer-relevant phenotypes.

Favicon imagepubmed.ncbi.nlm.nih.gov

Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis

January 1, 2024

Comparative genomic analyses of human translocation renal cell carcinoma (tRCC) cohorts, tumorgraft models, and novel genetically engineered mouse models to characterize molecular mechanisms of ASPSCR1-TFE3–driven tumorigenesis and identify convergent pathways (cell cycle, lysosome, mTORC1) and therapeutic opportunities.

Favicon imagepubmed.ncbi.nlm.nih.gov

Comparative genomic analysis of novel translocation renal cell carcinoma model reveals molecular mechanisms of disease progression and therapeutic opportunities (abstract)

August 1, 2023

Conference abstract (AACR) summarizing comparative genomic analyses of a tRCC model, highlighting molecular mechanisms and potential therapeutic targets.

Favicon imageaacrjournals.org

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer

January 1, 2018

Review discussing regulation and posttranslational modifications of PKM2 and their roles in cancer metabolism and tumor progression; G. Prakasam is listed among the article authors in the scholarly metadata.

Favicon imagefrontiersin.org