Lior Zelcbuch
VP R&D focused on synthetic biology and phage engineering
Summary
Work
Education
Projects
Writing
Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial
January 1, 2025Clinical study reporting safety, tolerability, pharmacokinetics and exploratory efficacy endpoints for a nebulized three-phage cocktail targeting Pseudomonas aeruginosa in cystic fibrosis patients.
Luminescent Phage-Based Detection of Klebsiella pneumoniae: From Engineering to Diagnostics
January 1, 2021Reports engineering of NanoLuc reporter phages for rapid, sensitive detection of a disease-associated Klebsiella pneumoniae strain in fecal samples as a diagnostic tool to support phage therapy.
Pyruvate formate-lyase enables efficient growth of Escherichia coli on acetate and formate
January 1, 2016Demonstrates the role of pyruvate formate-lyase in enabling E. coli growth on acetate and formate, contributing to understanding of central metabolism adaptations.
An In Vivo Metabolic Approach for Deciphering the Product Specificity of Glycerate Kinase Proves that Both E. coli’s Glycerate Kinases Generate 2-Phosphoglycerate
January 1, 2015Describes an in vivo metabolic selection strategy demonstrating that E. coli glycerate kinases produce 2-phosphoglycerate; uses engineered knockout strains and growth selection to resolve enzyme product specificity.
Spanning high-dimensional expression space using ribosome-binding site combinatorics
January 1, 2013Presents a modular method to span expression levels of multiple proteins in parallel using combinatorial pairing with ribosome-binding sites; applied to fluorescent reporters and metabolic pathways.