Sreekanth Chalasani
Neuroscientist developing sonogenetics and neural circuit tools
La Jolla, California
Summary
Pioneer of sonogenetics — leading development of ultrasound-based, noninvasive neuromodulation. nature+2
Uses a comparative, multi-model approach — applying C. elegans, zebrafish (Danio rerio) and mice to link molecular, cellular and circuit-level mechanisms to behavior. salk+1
Combines basic neuroscience with engineering and translational aims — advancing tool development (ion channel screens, ultrasound hardware) toward potential therapeutic applications and device concepts. nature+2
Established, well-cited researcher and lab leader — holds a chaired professorship at the Salk Institute with a substantial publication record and external funding. salk+2
Work
Education
Projects
Writing
US20230263891A1 - Sonogenetic stimulation of cells expressing TRPA1 (patent application)
August 1, 2023Patent application describing compositions and methods for expressing TRPA1 polypeptides/polynucleotides and inducing activation of TRPA1 in neurons and other cell types using ultrasound for sonogenetic stimulation.
Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels
February 1, 2022Identifies human TRPA1 (hsTRPA1) as an ultrasound-sensitive channel that confers ultrasound responsiveness to mammalian cells and demonstrates modulation of neurons in vivo using hsTRPA1-based sonogenetics.
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans
September 1, 2015Describes the use of low-pressure ultrasound and the mechanotransduction channel TRP-4 to activate genetically sensitized neurons in C. elegans, introducing the sonogenetics approach for noninvasive cellular manipulation.