Jessica Merryfield

Explains the need to broaden CGT site networks beyond traditional centers, outlines a four-dimension readiness framework (facilities, institution, department, staff) and strategies to enable emerging sites.

Practical operational advice for optimizing site selection, patient recruitment and engagement for gene therapy trials to reduce site burden and improve execution.

Overview of the emerging gene therapy landscape and high-level considerations for designing and conducting gene therapy clinical trials, including vector types, site selection and assessments.

Discussion of key considerations for designing gene therapy trials that balance safety oversight and evidence generation with logistical challenges like site capability, informed consent and patient readiness.