Deepak Jha
Senior Scientist, Data, AI & Genome Sciences at Merck
Cambridge, Massachusetts
Summary
Epigenetics and chromatin-focused scientist with sustained publication record in stem cell and hematopoiesis research. google+2
Translational researcher who moved from academic postdoctoral work to industry (Merck) to accelerate impact on patient health and engage in end-to-end drug discovery. unc+2
Combines experimental and computational approaches in daily work—designing and executing experiments while interpreting computational data and developing research strategies. unc+1
Active contributor to the scientific community and leadership in early-career forums (e.g., Gordon Research Seminar), with experience mentoring and presenting on career development. grc+1
Work
Education
Writing
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP (Erratum / final)
January 1, 2025Final edited form / erratum for the CAR T cells paper (Cell Stem Cell) correcting figure content without altering conclusions.
Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP
January 1, 2024Study showing that chemical inhibition of G9a/GLP during iPSC-derived T cell differentiation promotes generation of mature iPSC-T cells with enhanced effector functions and durable antitumor activity; includes work on epigenetic modulation to improve CAR-T cell properties.
TARGETING LYSINE DEMETHYLASES (KDMs) AS A THERAPEUTIC STRATEGY FOR DIFFUSE LARGE B-CELL LYMPHOMA (Patent, WO PCT/US2018/035,336)
January 1, 2019Patent application listing work on targeting lysine demethylases as a therapeutic strategy, co-authored with G. Q. Daley.
An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair
January 1, 2014Research on the role of H3K36 methylation in checkpoint activation and double-strand break (DSB) repair, reflecting doctoral-era work on chromatin and DNA repair mechanisms.