Matthieu Marfoglia
Computational biologist focused on protein dynamics and mechanotransduction
Lausanne, Switzerland
Summary
Matthieu is a computationally and experimentally fluent researcher focused on protein dynamics and mechanotransduction, with a PhD project that combined single‑molecule force spectroscopy, molecular dynamics and graph‑neural‑network approaches to study adhesion GPCR (ADGRG1) activation and to rationally design GAIN‑domain variants with altered mechanical sensitivity. epfl+1
He is affiliated with EPFL as a researcher (PhD 20202014 and postdoctoral researcher from 2024), and is visible in EPFL's people/graph records and lab pages, indicating active roles in lab seminars and funded projects on GPCRs and protein design. epfl+2
Early in his career Matthieu engaged in science communication and outreach (e.g., a 2020 article explaining probiotics), consistent with a trajectory that spans academic research and public-facing writing. hello-day
Work
Education
Projects
Writing
Molecular characterization of an adhesion GPCR signal transduction
January 1, 2025Preprint describing integrated single-molecule, simulation and cell‑based work that defines alternative activation pathways for ADGRG1 (GAIN domain shedding vs intact GAIN‑7TM coupling) and reports designed GAIN variants with tuned mechanical sensitivity.
Microbiota, Probiotics and Prebiotics
November 1, 2020A 2020 public-facing article on microbiota/probiotics authored while Matthieu was a Master's student at ENS Lyon.