Donnacha Fitzgerald

Doctoral dissertation summarizing the experimental and computational research showing differentiation-driven intratumor heterogeneity in B-cell lymphomas; methods, analyses, and implications for diagnosis and therapy.

Preprint and dataset describing a cross-entity single-cell and spatial atlas of nodal B-cell lymphomas, showing that intratumor heterogeneity is driven by differentiation states; includes CITE-Seq, CODEX spatial imaging, and survival deconvolution analyses.

Contributions to multiple collaborative papers arising from EMBL projects linking single-cell and spatial profiling to cancer biology (see ORCID / Google Scholar for full list).

Multimodal and spatial atlas study profiling T cell infiltration across nodal B-cell lymphoma entities, revealing quantitative and spatial aberrations in the tumor microenvironment.

Clinical study evaluating polatuzumab vedotin as salvage and bridging therapy for relapsed/refractory large B-cell lymphoma, reporting efficacy and safety outcomes.

Clinical analysis of aggressive lymphoma occurrences following CD19 CAR T-cell therapy, examining patient outcomes and implications for treatment strategies.

Methodological paper describing joint single-cell DNA–RNA sequencing to link genomic variants to functional phenotypes, enabling functional interpretation of variants at single-cell resolution.

Prospective study demonstrating ex vivo drug response profiling as a tool to predict chemotherapy response and outcomes in hematologic malignancies.