
Carlos L. Araya
Scientist–entrepreneur in genomics, biophysics, and variant interpretation
Network
2K connectionsSummary
Work
Education
Projects
Writing
Systems and Methods for the Interpretation of Genetic and Genomic Variants via an Integrated Computational and Experimental Deep Mutational Learning Framework (patent application)
January 1, 2018Patent applications describing computational and experimental frameworks for scalable, auditable variant interpretation that combine experimental functional data with predictive models.
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function
January 1, 2012Large-scale experimental study linking protein function measurements to thermodynamic stability, demonstrating how massively parallel functional assays can reveal fundamental protein properties.
Deep mutational scanning: assessing protein function on a massive scale
January 1, 2011A widely cited review/primer describing experimental and analytical approaches for deep mutational scanning and large-scale measurements of protein function.
High-resolution mapping of protein sequence–function relationships
January 1, 2010Work developing high-throughput experimental approaches to map the relationship between protein sequence and function at large scale; foundational to deep mutational scanning and variant-effect mapping.
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