Abhay Tharmatt
Nanocarrier and gene-editing researcher focused on dermatological therapeutics
Summary
Work
Education
Projects
Writing
Lipopolymeric Nanoplex‑Mediated CRISPR/Cas9 Delivery for VEGF‑A Knockdown in Psoriatic Angiogenesis
October 1, 2025Detailed report of NPX-encapsulated sgRNA/Cas9 RNPs targeting VEGF-A with characterization, ex vivo skin permeation, formulation into gel, and in vivo efficacy in psoriasis models (indel frequencies and therapeutic outcomes reported).
Can breakthroughs in dermal and transdermal macromolecule delivery surmount existing barriers and revolutionize future therapeutics?
May 1, 2025A review discussing strategies, mechanical and chemical enhancement techniques, and nanotechnology-based approaches to improve dermal/transdermal delivery of macromolecules.
Eugenol‑Loaded Lipid Nanoparticles‑Derived Hydrogels Ameliorate Psoriasis‑like Skin Lesions by Lowering Oxidative Stress and Modulating Inflammation
October 1, 2024Study of eugenol-loaded lipid nanoparticles formulated into Carbopol hydrogel (EUNPGel) showing ROS scavenging, inhibition of keratinocyte proliferation, dermal penetration and significant reduction in PASI score in imiquimod-induced psoriasis models.
Lipo‑polymeric nano-complexes for dermal delivery of a model protein
June 1, 2024Describes preparation and characterization of cationic lipo-polymeric nanocarriers complexed with a model protein (FITC-BSA), formulation into carbopol gel, and demonstration of ex vivo/in vivo permeation and low toxicity — supporting dermal delivery of macromolecules.
cRGD‑modified hybrid lipopolymeric nanoplexes for gene editing in the posterior segment of the eye
May 1, 2024Development of cRGD‑modified lipopolymeric nanoplexes for Cas9 RNP delivery to retinal tissues, demonstration of in vitro transfection and in vivo vitreous mobility and retinal transfection with measurable gene-editing activity.
Novel Therapeutics Involving Antibiotic Polymer Conjugates for Treating Various Ailments: A Review
June 1, 2022Review of antibiotic polymer conjugates (APCs) covering mechanisms, routes of administration, and potential applications including topical and ocular delivery routes.