
Neel Shanmugam
Co-Founder & COO at Cluely | Columbia dropout | AI innovator
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4.6K connectionsSummary
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Education
Writing
Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition
November 1, 2024Investigated the effects of the PARP1 variant V762A (associated with cancers) on PARP1 inhibition by FDA-approved inhibitors (niraparib, rucaparib, talazoparib). Suggested these inhibitors bind more effectively to the V762A mutant. Talazoparib uniquely lowered average residue fluctuations in the mutant.
Comments regarding βSolubility determination and crystallization thermodynamics of an intermediate in different organic Solventsβ
January 1, 2021A polemic concerning mathematical equations used to describe mole fraction solubility variation of 4-nitropyrazole with temperature, noting inconsistencies in published values and re-calculating curve-fit coefficients.
Notes
Feb 20, 2026
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