Esther Melo
BD&L Director at Roche Pharma Partnering
Summary
Work
Education
Projects
Writing
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
January 1, 2018Paper describing a polarized human fetal retinal pigment epithelial cell model to study how altered HtrA1 levels affect RPE physiology and intracellular tubulin, with implications for age-related macular degeneration (AMD).
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
January 1, 2017Study combining computational and experimental approaches to describe activation and regulation mechanisms of human HtrA1 protease, showing inter-monomer allosteric communication in the HtrA1 trimer and implications for disease-relevant substrates.
Development of a Bronchial Wall Model: Triple Culture on a Decellularized Porcine Trachea
January 1, 2015Research article presenting an in vitro bronchial wall co-culture model using decellularized porcine trachea membrane and three human cell types to better recapitulate airway mucosa for regenerative medicine and pharmacology studies.
Effects of the decellularization method on the local stiffness of acellular lungs
January 1, 2014Study measuring how different decellularization procedures affect the inhomogeneous local stiffness of acellular lung matrix using atomic force microscopy.
Effects of freezing/thawing on the mechanical properties of decellularized lungs
January 1, 2014Investigation of how repeated freeze–thaw cycles influence the ventilation mechanical properties (resistance and elastance) of decellularized lungs.