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Stephen Thaddeus Connelly

Stephen Thaddeus Connelly

Healthcare Innovator, Oral & Maxillofacial Surgeon, Educator, and Venture Partner

San Francisco, California
Palo Alto, California
Joined August 2025

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Summary

Stephen Thaddeus Connelly is a highly educated and multi-faceted oral and maxillofacial surgeon with a DDS from Columbia University, an MD and PhD in Craniomaxillofacial Sciences from UCSF. He is a Full Professor at UCSF, actively involved in teaching students and residents, and holds the prestigious Fellow of the American College of Surgeons (FACS) designation. songoralsurgery+3
His clinical practice and research are extensively focused on temporomandibular joint (TMJ) disorders and surgery, dental implantology, dentoalveolar surgery, and sleep apnea. He has authored and edited several books and numerous articles on these subjects, demonstrating his expertise and contributions to the field. diossf+3
Beyond his clinical and academic roles, Dr. Connelly is an entrepreneur, co-founding Boutique Venture Partners, a healthcare-focused venture capital firm, and GengyveUSA, a company developing oral health products. He also serves as CEO of Adirondack Distribution Group, showcasing a blend of medical and business acumen. apple+2
Dr. Connelly's research interests span a wide range, including artificial intelligence and humanoid robotics, bioethical implications, molecular markers of metastasis, and the use of cutting-edge technologies like 3D printing and machine learning in craniofacial surgery and oncology. His work on "Quantum Distillery" blog suggests an interest in quantum mechanics and its relation to health. researchgate+2

Work

Education

Writing

Regeneration of Critical-Sized Mandibular Defects Using 3D-Printed Composite Scaffolds: A Quantitative Evaluation of New Bone Formation in In Vivo Studies.

February 1, 2023

A study on the use of 3D-printed composite scaffolds for regenerating critical-sized mandibular defects and evaluating new bone formation.

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Condylar Position is Maintained in Maxillomandibular Advancement Surgery Utilizing Custom Cutting Guides and Plates.

February 1, 2023

Research investigating the maintenance of condylar position in maxillomandibular advancement surgery using custom cutting guides and plates.

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Contact ratio and adaptations in the maxillary and mandibular dentoalveolar joints in rats and human clinical analogs.

December 1, 2022

Research on contact ratio and adaptations in dentoalveolar joints using rat models and human clinical analogs.

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A machine learning model for separating epithelial and stromal regions in oral cavity squamous cell carcinomas using H&E-stained histology images: A multi-center, retrospective study.

August 1, 2022

A study on a machine learning model for distinguishing epithelial and stromal regions in oral cavity squamous cell carcinomas from histology images.

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Recent advances in graphene-based nanobiosensors for salivary biomarker detection.

January 1, 2021

A review of recent advancements in graphene-based nanobiosensors for detecting salivary biomarkers.

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Temporomandibular Joint Discectomy Followed by Disc Replacement Using Viable Osteochondral and Umbilical Cord Allografts Results in Improved Patient Outcomes.

January 1, 2020

Research on improved patient outcomes from TMJ discectomy and disc replacement using viable osteochondral and umbilical cord allografts.

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Contemporary Management of Temporomandibular Disorders (3 volumes)

January 1, 2019

Edited three volumes providing a comprehensive overview of temporomandibular disorders, including fundamentals, diagnosis, and surgical treatment.

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Clinical outcomes of Botox injections for chronic temporomandibular disorders: do we understand how Botox works on muscle, pain, and the brain?

November 1, 2016

Research article exploring the clinical efficacy and mechanisms of Botox injections for chronic temporomandibular disorders.

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Mouthwashes in the 21st century: a narrative review about active molecules and effectiveness on the periodontal outcomes.

November 1, 2016

Review article discussing active molecules and effectiveness of modern mouthwashes on periodontal health.

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Normalizing surface electromyographic measures of the masticatory muscles: Comparison of two different methods for clinical purpose.

October 1, 2016

Research article comparing two methods for normalizing surface electromyographic measures of masticatory muscles for clinical application.

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Early Detection and Treatment of Head & Neck Cancers: Theoretical Background and Newly Emerging Research

Authored and edited a book providing an up-to-date overview of head and neck cancer, covering epidemiology, etiology, diagnosis, and treatment advancements.

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The Benefits of Using the Ultrasonic BoneScalpel in Temporomandibular Joint Reconstruction.

Journal article detailing the advantages of using the ultrasonic BoneScalpel in temporomandibular joint reconstruction.

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Editorial: Saliva used as biological fluid to detect neurodegenerative and neurodevelopmental diseases.

An editorial discussing the potential of saliva as a biological fluid for detecting neurodegenerative and neurodevelopmental diseases.

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Dietary supplements for improving nitric-oxide synthesis.

An article discussing dietary supplements that can improve nitric oxide synthesis.

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Polyphenols andin oral health.

An article focusing on the role of polyphenols in oral health.

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Ethical considerations regarding animal experimentation.

A publication addressing the ethical considerations involved in animal experimentation.

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Metabolomics application for the design of an optimal diet.

An article on the application of metabolomics in designing optimal diets.

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Methodology for clinical research.

A publication outlining methodologies for conducting clinical research.

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Physical activity for health.

An article on the benefits of physical activity for overall health.

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Validating methods for testing natural molecules on molecular pathways of interest in silico and in vitro.

A study on validating methods for testing natural molecules on molecular pathways using both in silico and in vitro approaches.

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Main nutritional deficiencies.

An article discussing common nutritional deficiencies.

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Cone-Beam Computed Tomographic Assessment of the Mandibular Condylar Volume in Different Skeletal Patterns: A Retrospective Study in Adult Patients.

A retrospective study on assessing mandibular condylar volume using cone-beam computed tomography in adult patients with various skeletal patterns.

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Clinical Outcome of Dental Implants after Maxillary Sinus Augmentation with and without Bone Grafting: A Retrospective Evaluation

A retrospective evaluation of the clinical outcomes of dental implants following maxillary sinus augmentation, with and without bone grafting.

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Electroporation technique for joint pain - Pilot feasibility study on TMD patients.

A pilot feasibility study on the use of electroporation technique for treating joint pain in temporomandibular disorder patients.

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A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic

An article advocating for safe delivery of oral health care during and after the COVID-19 pandemic.

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3D cephalometry on reduced FOV CBCT: skeletal class assessment through AF-BF on Frankfurt plane-validity and reliability through comparison with 2D measurements.

A study validating the reliability of 3D cephalometry on reduced field of view CBCT for skeletal class assessment.

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Bilateral Temporomandibular Joint Reconstruction and Maxillomandibular Advancement for Concomitant Temporomandibular Joint Degeneration and Obstructive Sleep Apnea

A research paper on surgical approaches for treating both temporomandibular joint degeneration and obstructive sleep apnea.

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Use of Viable Cryopreserved Placental Membrane as an Adjunct to Facial Keloid Resection

A study on using viable cryopreserved placental membrane as an adjunct treatment for facial keloid resection.

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Implant rehabilitation in fibula-free flap reconstruction: A retrospective study of cases at 1-18 years following surgery.

A retrospective study examining implant rehabilitation outcomes after fibula-free flap reconstruction over an extended period.

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Semi-Quantitative Models for Identifying Potent and Selective Transthyretin Amyloidogenesis Inhibitors

Research on developing semi-quantitative models to identify potent and selective inhibitors for transthyretin amyloidogenesis.

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Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon

A study on stabilizing the CH2 domain of an antibody through engineering an enhanced aromatic sequon.

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A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

Research on a fluorogenic compound for imaging transthyretin within organelles in living cells and C. elegans.

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Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis.

A study on the role of Akt phosphorylation and transketolase regulation in amino acid control of purine synthesis.

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Fluorogenic Small Molecules Requiring Reaction with a Specific Protein to Create a Fluorescent Conjugate for Biological Imaging–What we Know and What we Need to Learn

An article discussing fluorogenic small molecules that form fluorescent conjugates with specific proteins for biological imaging.

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Notes

TPThomas Powersaid that if they were starting a healthcare company at the pre-seed stage,
STStephen Thaddeus Connelly
would be on their short list of investors.

Mar 4, 2026