Michael Sweet

A practitioner-focused blog post discussing common misunderstandings about GLP preclinical studies and guidance for planning and executing regulatory-grade preclinical work.

Evaluation of the Sentry IVC filter in an ovine model, assessing deployment success, stages of bioconversion and incorporation into the vessel wall, and device-related outcomes through 180 days.

Describes an endovascular technique to produce a durable large-animal model of ischemic myopathy suitable for testing novel therapeutics for PAD and CLI.

Investigation of a novel sustained-release sodium nitrite formulation in an Ossabaw swine model of CLI and metabolic syndrome, reporting cytoprotective and proangiogenic signaling in ischemic tissues.

In-vitro experimental comparison of three surgical repair techniques (neochordoplasty, limited triangular resection, edge-to-edge repair) for anterior leaflet flail, quantifying hemodynamic and echocardiographic indices.

Study of a sustained-release nitrite formulation that increased myocardial nitrite levels, reduced oxidative stress, and improved coronary vascular function in an obese porcine model with peripheral vascular disease.