Israel Pichardo-Casas
Geroscientist focused on peptidomics, mitochondrial biology, longevity
Summary
Work
Education
Projects
Writing
Mitochondrial Dysfunction Induces Hepatic Lipid Accumulation and Inflammatory Responses in mtDNA Mutator Mice
April 1, 2025Preprint reporting that mitochondrial dysfunction in mtDNA mutator mice induces liver steatosis and inflammation independent of obesity, using quantitative mass spectrometry and functional assays.
Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila
January 1, 2022Describes discovery and functional characterization of two conserved smORF-encoded peptides (Sloth1 and Sloth2) in Drosophila that localize to mitochondria and regulate mitochondrial complex III assembly and neuronal function.
Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography
April 1, 2021Developed a reproducible workflow (Pre-SEC) to isolate extracellular vesicle subgroups and performed quantitative proteomics to characterize early- and late-eluting EV fractions, revealing compositional heterogeneity.
MicroRNAs Regulate Multiple Aspects of Locomotor Behavior in Drosophila
January 1, 2020Study using miRNA sponge library in Drosophila to identify microRNAs that modulate locomotor behavior, indicating many miRNAs act within the nervous system and at different life stages.
Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation
January 1, 2015Characterized regional and synaptic distribution of microRNAs in adult rat brain and showed selective modulation of synaptic miRNA content after excitatory stimulation (kainic acid model).