Yusuf Erkul

Provides lipid nanoparticle compositions and methods of use with increased specificity for specific cells or tissues.

Technologies for treating cancer using oncoselective construct designs encoding payloads of high therapeutic interest, recognizing advantages of combining with immune checkpoint therapy.

Technologies for achieving oncoselective translation by identifying oncoselective sequence motifs to engineer synthetic DNAs or mRNA constructs for cancer cell-specific protein expression.

Methods and compositions useful for induction of cell death, specifically translatable nucleic acids encoding constitutively active payloads capable of inducing immunogenic cell death.

Methods for lowering immunogenicity in long polynucleotide sequences through precise sequence engineering of immunogenic motifs, resulting in improved functionality like low innate immunogenicity, improved stability, or high protein expression.