Zhe J. Liu

Work demonstrating that cohesin helps neutralize stochastic coexpression of cis-linked genes in single cells by arranging nuclear topology to control gene coexpression and prevent long-range gene co-bursting.

Study showing that neurons off-load damaged fatty acids to astrocytes, which recycle them via mitochondrial metabolism to protect neurons from activity-induced lipid toxicity.

Review discussing recent technological advances in imaging and single-cell genomics and proposing integrated approaches to decode in vivo cellular dynamics and molecular mechanisms during development.

A single-cell, single-molecule study that quantified how transcription factors (Sox2/Oct4) search for and assemble on DNA in live embryonic stem cells, revealing 3D diffusion-dominated search behavior, 1D sliding, and a hierarchical ordering of enhanceosome assembly.