Luke M. Oltrogge
Biophysical chemist — molecular self‑assembly, protein organization, and measurement methods
Summary
Work
Education
Writing
A map of the Rubisco biochemical landscape
January 1, 2025Large‑scale biochemical mapping of Rubisco variants and kinetic parameters; collaborative work contributing to an atlas of Rubisco function and evolution.
α‑Carboxysome Size Is Controlled by the Disordered Scaffold Protein CsoS2
January 1, 2024Demonstrates that the disordered scaffolding protein CsoS2 specifies α‑carboxysome size via repeat motifs that modulate shell curvature and mechanics; combines biochemical reconstitution, imaging, and modeling to propose a size‑control model.
Rubisco forms a lattice inside α‑carboxysomes
August 1, 2022Structural work showing the internal organization of Rubisco inside α‑carboxysomes, informing how packing and organization contribute to carboxysome function.
Multivalent interactions between CsoS2 and Rubisco mediate α‑carboxysome formation
January 1, 2020Describes how multivalent binding between the scaffold CsoS2 and Rubisco drives formation of α‑carboxysomes, providing mechanistic insight into cargo–scaffold interactions central to microcompartment assembly.