Luke Riggan
Immunologist and investor focused on in vivo cell therapies
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Author Correction: MEF2C regulates NK cell effector functions through control of lipid metabolism
April 1, 2024Correction notice (Nature Immunology) listing authors including Luke Riggan; related to work on MEF2C's role in NK cell effector function and lipid metabolism.
The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection
January 1, 2022Research article identifying transcriptional and epigenetic NK effector states and demonstrating that Fli1 limits memory-precursor NK cell formation via regulation of pro-apoptotic pathways; uses single-cell RNA-seq and functional studies in mouse MCMV infection.
Arrested development: suppression of NK cell function in the tumor microenvironment
January 1, 2021Review summarizing mechanisms that impair NK cell recruitment and function within solid tumor microenvironments and discussing strategies to enhance adoptive NK cell therapies and overcome intrinsic/extrinsic checkpoints.
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Enjoys outdoor activities (hiking, camping), rock climbing, basketball, weight lifting, and spending time with his Samoyed dog. polygence
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