Everett J. Perkins
Executive Director, External Partnering & Translational Biology at Eli Lilly
Summary
Work
Education
Writing
ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective (chapter contribution / acknowledgments)
September 1, 2023A chapter reviewing ADME principles and study designs across discovery and development phases; Everett Perkins is listed among individuals who provided insights to the chapter.
Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse
December 1, 2016Study evaluating five blood microsampling techniques for mouse pharmacokinetic studies and recommending practical approaches (e.g., saphenous bleeding) to enable serial sampling and improve data quality while reducing animal use.
Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure
May 1, 2013Preclinical studies evaluating the pharmacokinetics, metabolism, and excretion of LY2334737, an oral amide prodrug of gemcitabine; identified contribution of carboxylesterase 2 (CES2) to hydrolysis and characterized in vitro and in vivo disposition across species.
Selected publications and contributions in drug metabolism and pharmacokinetics (Research profile)
Research profile listing publications and research interests including carboxylesterases, prodrugs, mechanistic PK modeling, and contributions to discovery and regulatory submissions.