Profile banner
Larry Norton

Larry Norton

Senior vice president and leading breast medical oncologist

New York, New York
mskcc
Favicon imagemskcc.org
Favicon imagevivo.weill.cornell.edu
Favicon imageorcid.org

Summary

Prominent clinical and institutional leader in breast oncology: Dr. Norton serves in senior leadership at Memorial Sloan Kettering (Senior Vice President, deputy physician-in-chief for breast programs) and directs the Evelyn H. Lauder Breast Center, combining patient care with oversight of clinic-oriented programs. mskcc+1
Biomathematician who shaped chemotherapy scheduling: Norton co-developed the Norton–Simon hypothesis and has applied mathematical growth models to optimize dose and schedule, work that influenced dose-dense chemotherapy approaches. nih+1
Longstanding research and advocacy focus on metastatic breast cancer: As founding Scientific Director of the Breast Cancer Research Foundation and participant in large international projects (e.g., AURORA), he has led efforts to understand and prevent metastasis, including promoting the self-seeding model of tumor progression. bcrf+2
Educator, prolific author, and national leader: Dr. Norton is a professor of medicine, has authored hundreds of articles, served as ASCO president, and was a U.S. Presidential appointee to the National Cancer Advisory Board, reflecting broad influence in clinical oncology, research, and policy. cornell+2

Work

Education

Projects

Writing

International research to address the challenges of metastatic breast cancer: the AURORA Program (BIG 14-01)

January 1, 2023

Overview of the AURORA international program focused on understanding metastatic breast cancer and coordinating academic, translational research efforts across countries and institutions.

Favicon imagepubmed.ncbi.nlm.nih.gov

Clinical implications of cancer self-seeding

January 1, 2011

Review describing the self-seeding model of metastasis, in which circulating tumor cells can return to and re-infiltrate the primary tumor, with implications for tumor progression and metastasis.

Favicon imagepubmed.ncbi.nlm.nih.gov

Optimizing chemotherapy dose and schedule by Norton–Simon mathematical modeling

January 1, 2010

Application of Norton–Simon modeling to preclinical dose-scheduling data demonstrating how mathematical approaches can predict improved dosing schedules (example: capecitabine schedules in xenograft models).

Favicon imagepubmed.ncbi.nlm.nih.gov

The Norton-Simon hypothesis: designing more effective and less toxic chemotherapeutic regimens

January 1, 2006

Discussion of the Norton–Simon hypothesis, which uses mathematical modeling of tumor growth to design dose schedules that aim to improve efficacy and reduce toxicity of chemotherapy.

Favicon imagepubmed.ncbi.nlm.nih.gov

Hobbies

Serious musician — plays vibraphone, electric bass, and mandolin. cancernetwork+1