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Brandon S. Nichols

Brandon S. Nichols

Founding Engineer & Lead Systems Architect; biophotonics researcher

New York, New York, United States
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Joined March 2026
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Summary

Experienced biophotonics researcher and instrument developer — Brandon has an extended publication record and technical contributions in diffuse optical spectroscopy, fluorescence, and Raman modalities for biomedical diagnostics, particularly tumor margin assessment and skin cancer diagnosis. nih+3
Translational engineer focused on compact, practical devices — work includes developing portable intra-operative and point-of-care imaging devices (QDRI, POCkeT Colposcope, annular photodiode imaging systems) aimed at clinical utility and deployment. nih+2
Bridges academia and industry — sustained academic research at Duke (graduate research and postdoctoral work) followed by engineering roles in industry and a founding engineering position at Arlow, indicating experience moving research prototypes toward product development. researchgate+2
Collaborative co-author and multidisciplinary contributor — co-authored numerous multi-author papers spanning biomedical optics, device engineering, and clinical studies, showing collaboration across engineering, surgery, and pathology. nih+2

Work

Education

Projects

Writing

A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins

January 1, 2015

Description and clinical pilot validation of a next-generation multiplexed optical-fiber-based tool to assess breast tumor margin status during breast-conserving surgery, including system optimizations and pilot patient results.

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Clinical study of noninvasive in vivo melanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

January 1, 2014

Clinical evaluation of a multimodal spectral diagnosis system (reflectance, fluorescence, Raman) for noninvasive diagnosis of melanoma and nonmelanoma skin cancers, reporting high diagnostic accuracy for several lesion classifications.

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A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays

January 1, 2012

Design and characterization of a fiberless, multipixel diffuse reflectance spectroscopy imaging system using custom annular photodiode arrays for intra-operative tumor margin assessment.

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Development of a noncontact diffuse optical spectroscopy probe for measuring tissue optical properties

January 1, 2011

Methods and validation for a noncontact diffuse optical spectroscopy probe intended to measure tissue optical properties accurately and robustly.

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