Matthew Workentine
Bioinformatics technical lead and computational biologist
Summary
Work
Education
Projects
Writing
US20240101994A1 — Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
March 28, 2024Patent application/granted publication on engineered olivetolic acid cyclase (OAC) polypeptides and their use in recombinant host systems to improve cannabinoid precursor production.
WO2022204007A2 — Recombinant polypeptides for enhanced biosynthesis of cannabinoids
September 29, 2022Patent application disclosing recombinant cannabinoid synthase polypeptides and N-terminal secretion peptides useful for enhanced biosynthesis of cannabinoids in recombinant host cells.
Automated Hypothesis Generation to Identify Signals Relevant in the Development of Mammalian Cell and Tissue Bioprocesses, With Validation in a Retinal Culture System
June 1, 2020Developed an accessible software tool (receptoR) to predict potentially active signaling pathways in cell types of interest from public transcriptome data, validated in a retinal culture system.
Topography of the respiratory tract bacterial microbiota in cattle
January 1, 2020Characterized bacterial microbiota across multiple respiratory tract niches in cattle, identifying nasopharynx as most similar to lung microbiota and highlighting niche-specific communities.
Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury
January 1, 2020Study examining the role of Muc2 mucin and microbiota in colonic barrier function and inflammation, using Muc2-deficient and sufficient littermates and microbiota manipulations.