Philip C. Wong
Professor of Pathology and Neuroscience researching neurodegeneration
Baltimore, Maryland
Summary
Established leader in molecular mechanisms of neurodegeneration focused on TDP-43 and amyloid biology. jhu+2
Translational researcher developing biomarkers and gene-therapy strategies to enable earlier diagnosis and therapeutic intervention for ALS–FTD and Alzheimer's disease. nature+1
Lab director and mentor who builds and leads multidisciplinary teams combining pathology, neuroscience and biomedical engineering to advance disease models and therapeutics. jhu+1
Prolific, highly cited academic with an extensive publication record and active roles in research leadership, peer review and professional societies. google+1
Work
Education
Projects
Writing
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD
January 1, 2024Describes development of a monoclonal antibody and a fluid assay for a cryptic exon-encoded neoepitope (cryptic HDGFL2) and shows that loss of TDP-43 splicing repression occurs presymptomatically in familial and sporadic ALS–FTD, establishing a potential diagnostic biomarker.
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
January 1, 2015Demonstrates that TDP-43 functions to repress nonconserved cryptic exons and that this repression is compromised in ALS–FTD, implicating loss of TDP-43 splicing repression in disease mechanism.